Effect of bond strength variation and ionizing radiation on mutations in cytosine-guanine islands*
Presentation Type
Poster Presentation
Mentor/Supervising Professor Name
Andrianarijaona, Vola
Abstract (Description of Research)
Ionizing radiation produces free electrons within cells which ionizes DNA and has potential to cause carcinogenic mutations. CpG islands are regions that are rich in cytosine and guanine bases and are common sites of single point mutations and strand breaks. DFT is used to calculate the potential energy of DNA nucleotide dimers varying bond lengths in five different ionized states. Potential energy curves are used to determine bond stability, and electron density of atoms of interest are compared at specific bond lengths between ionized states. This provides insight into patterns and possible mechanisms of mutation resulting from ionizing radiation.
Effect of bond strength variation and ionizing radiation on mutations in cytosine-guanine islands*
Ionizing radiation produces free electrons within cells which ionizes DNA and has potential to cause carcinogenic mutations. CpG islands are regions that are rich in cytosine and guanine bases and are common sites of single point mutations and strand breaks. DFT is used to calculate the potential energy of DNA nucleotide dimers varying bond lengths in five different ionized states. Potential energy curves are used to determine bond stability, and electron density of atoms of interest are compared at specific bond lengths between ionized states. This provides insight into patterns and possible mechanisms of mutation resulting from ionizing radiation.