Mentor

Liedke, Mike

Document Type

Dissertation

Publication Date

2019

Abstract

Sepsis is a major epidemic worldwide and is a large unmet medical need in this country. Annual costs for the treatment of sepsis are over $3.4 billion dollars, and over 1.7 million people die each year from sepsis. Effective treatment of sepsis has two major obstacles: failure to recognize the early stages of sepsis and misjudging the severity of the disease. Identifying patients who are at higher risk for mortality and morbidity related to sepsis would be beneficial in keeping the numbers of deaths down, as well as decreasing the overall cost to the hospitals, as well as to the patient.

Albumin is a significant part of the plasma proteins that are important in maintaining oncotic pressure, permeability of the microvascular structures, acid base balance and prevent platelet aggregation. The aim of this study is to investigate the correlation between admission albumin levels and mortality in patients admitted from the emergency department with the diagnosis of sepsis.

The purpose of this quantitative, descriptive, retrospective, correlational study was to examine the relationship between low admission albumin levels and mortality in patients >18 years of age admitted through the emergency department with sepsis. Low admission albumin levels were evaluated for association and predictive ability to the outcome of mortality. In addition, age, gender and ethnicity were also evaluated for association and predictive ability in relation to low admission albumin levels and mortality.

There was a statistically significant correlation between low admission albumin levels and mortality. There was no statistical significant correlation between gender and mortality in regards to low admission albumin levels. There was significant negative correlation between age and mortality in patients with low albumin levels.

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