A Novel Method for the Synthesis of Phosphindolizine.
Presentation Type
Oral Presentation
Mentor/Supervising Professor Name
Dr. Matthew Duffy
Description
The purpose of this experimental design is to devise a novel method for the synthesis of phosphindolizine. The proposed mechanism includes the synthesis of 3,4-dimethyl – 2Hphospole, and 3,4-dimethyl-1-phenyl-, 1-sulfide. These two products will be reacted together via a 2+4 Diels alder reaction to create a 7-phosphanorbornene, and the phosphorous groups in the compound will be protected by adding sulfur (S8). The bicyclic portion of this ring will then be removed via UV light in a retro-Diels Alder reaction. Following the removal of the sulfur protecting group, this represents the proposed mechanism for synthesizing phosphindolizine.
A Novel Method for the Synthesis of Phosphindolizine.
The purpose of this experimental design is to devise a novel method for the synthesis of phosphindolizine. The proposed mechanism includes the synthesis of 3,4-dimethyl – 2Hphospole, and 3,4-dimethyl-1-phenyl-, 1-sulfide. These two products will be reacted together via a 2+4 Diels alder reaction to create a 7-phosphanorbornene, and the phosphorous groups in the compound will be protected by adding sulfur (S8). The bicyclic portion of this ring will then be removed via UV light in a retro-Diels Alder reaction. Following the removal of the sulfur protecting group, this represents the proposed mechanism for synthesizing phosphindolizine.